Peter Thomas Roth Peptide Skinjection Amplified Wrinkle-Fix Serum — Refillable, 19% Peptides for Firmer-Looking Skin

Peter Thomas Roth Peptide Skinjection™ Amplified Wrinkle-Fix Serum is a refillable, peptide-rich topical treatment designed to visibly reduce the look of expression lines and help support firmer-looking skin without needles.

This serum combines multiple concentrated peptides and peptide complexes in a dual-purpose formula meant to deliver needle-free results or to be used alongside professional injectables. The formula layers targeted peptides—Matrixyl variants and Argireline derivatives—with additional peptide boosters to address the visible signs of expression lines and the early stages of loss of firmness. The product comes in a refillable system to reduce waste and simplify routine application.

How does this serum help soften the look of expression lines?

The formula uses a high total peptide concentration to target the visible depth and shadowing of dynamic lines. Peptides work at the surface to support smoother-looking skin texture and may help reduce the appearance of creasing from repeated facial movements.

• 19% total peptide complex including Matrixyl and Argireline variants
• 10% Argirelox™ peptide booster to extend topical results
• Lightweight, fast-absorbing serum base for layered routines

Can I use this with in-office injectables or instead of them?

The serum is formulated to complement professional treatments or to be used on its own for non-invasive results. It was evaluated in studies involving post-injection use, but it is also intended as part of a standalone daily regimen for those seeking topical support.

• Designed for use after professional neurotoxin treatments or alone
• Refillable format supports ongoing maintenance without additional packaging
• Apply twice daily during your morning and evening skincare steps

What are the active peptides and how do they differ?

The serum blends multiple peptide types to address different aspects of visible aging: Matrixyl variants focus on supporting skin structure and texture, while Argireline derivatives target the appearance of movement-related lines. Each peptide has a distinct role so the combined effect aims to be broader than any single ingredient alone.

• Matrixyl Morphomics and Matrixyl Synthe’6 for structural support
• Argireline Amplified and Argirelox™ for movement-related line appearance
• Synergistic concentrations intended for visible, topical results

Who is this for? This refillable Peter Thomas Roth serum is formulated for adults of all skin types who want a concentrated, topical peptide treatment to visibly reduce expression lines and support firmer-looking skin. It's suitable for people seeking a non-invasive alternative to injectables, those who want to extend the visible benefits of professional treatments, or anyone wanting a high-strength peptide serum to incorporate into morning and evening routines. Avoid use if you have known sensitivity to any listed peptides or formulation components and consult a professional for personalized advice.

Ingredients

Water/Aqua/Eau, Dimethicone, Squalane, Butylene Glycol, Glycerin, Saccharomyces Lysate, Polysilicone-11, Acetyl Hexapeptide-8, Pentapeptide-18, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Palmitoyl Tripeptide-38, Collagen, Sodium Hyaluronate, Tocopherol, Phytosterols, Hydrogenated Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Citric Acid, Caprylic/Capric Triglyceride, Polyglyceryl-10 Myristate, Pentylene Glycol, Caprylyl Glycol, Sodium Benzoate, Sodium Phytate, Sodium Hydroxide, Potassium Sorbate, Ethylhexyl Palmitate, Hydroxypropyl Cyclodextrin Trihydroxystearin, Lauroyl Lysine, Glucomannan, Ethylhexylglycerin, Ammonium Acryloyldimethyltaurate/VP Copolymercarbomer, Glyceryl Stearate, Stearyl Alcohol, Behenyl Alcohol, Mica, Phenoxyethanol.