NIOXIN System 4 Scalp + Hair Shampoo for Color-Treated, Damaged Hair — 33.8 fl oz, Niacinamide & Biotin for Fuller-Looking Hair

Nioxin System 4 Scalp + Hair Shampoo is a professional derma-purifying cleanser formulated to gently remove buildup and support thicker-looking, color-treated, damaged hair with progressed thinning.

Built as the first step of Nioxin’s three-part regimen, System 4 combines Pro-Color Shield and Activ Renewal technologies to clear sebum, fatty acids, and environmental residue from the scalp and hair without stripping color or moisture. This salon-developed shampoo is clinically and dermatologically tested and designed to prep the scalp and fiber for the System 4 conditioner and scalp treatment, helping hair appear fuller and more resilient over time.

How does this shampoo help hair that’s been color treated and damaged?

System 4 targets the combined needs of color-treated and chemically stressed strands by cleansing gently while preserving hue. Its formula removes pore-clogging debris and environmental residue that can weigh hair down, creating a cleaner base so hair looks fuller and color stays vibrant.

• Pro-Color Shield to protect salon color during cleansing
• Activ Renewal technology lifts sebum and fatty deposits from the scalp
• Moisturizing agents that reduce dryness on chemically treated hair

Will this product actually make hair look thicker or fuller?

Nioxin System 4 is engineered to amplify the appearance of density by strengthening hair structure and reducing the effects of residue that masks natural volume. Users report improved fullness with consistent use as the three-step regimen rebuilds the hair’s visual thickness.

• Clinically designed to increase hair density and fullness with daily use
• Removes factors that cause strands to clump, restoring lift at the roots
• Works as step one in a system for cumulative results

How should I use System 4 for best results?

Apply to wet hair, massage the cleanser into the scalp and hair, allow a 60-second lather, then rinse thoroughly. For optimal performance, follow with Nioxin System 4 Scalp Therapy Conditioner and the Scalp and Hair Treatment as part of the full regimen.

• Daily use recommended for progressive thinning concerns
• Massage-focused application encourages cleansing at the root
• Pair with System 4 conditioner and treatment for improved outcomes

Is this shampoo suitable for sensitive scalps and how is it tested?

Formulated to respect scalp health, System 4 has undergone dermatological testing and aims to cleanse without over-drying. Its salon-origin formulation balances removal of impurities with moisturization to reduce irritation risks on chemically treated scalps.

• Dermatologically tested for scalp compatibility
• Designed to remove follicle-clogging debris while maintaining moisture
• Gentle enough for daily use on color-treated hair

Who is this for: Nioxin System 4 Scalp + Hair Shampoo is intended for people with dry, damaged, or color-treated hair experiencing progressed thinning who want a professional-strength cleansing step that prepares the scalp and hair for a thickening regimen. Ideal for those seeking salon-grade scalp care, daily use as part of the three-step System 4 can help improve the look of hair fullness while protecting color and addressing residue that hides natural volume.

Ingredients

Aqua, Sodium Laureth Sulfate, Sodium Lauryl Sulfate, Citric Acid, Sodium Chloride, PPG-2 Hydroxyethyl Coco/Isostearamide, Sodium Citrate, Sodium Xylenesulfonate, Sodium Benzoate, Salicylic Acid, Sodium Hydroxide, Tetrasodium EDTA, Mentha Piperita Oil, Mentha Arvensis Leaf Oil, Menthol, Trisodium Ethylenediamine Disuccinate, Methylparaben, Polyquaternium-10, Propylene Glycol, Camellia Sinensis Leaf Extract, Cystine Bis-PG-Propyl Silanetriol, Biotin, Lecithin, Niacinamide, Panthenol, Tocopheryl Acetate, Foeniculum Vulgare Fruit Extract, Sodium Acetate, Isopropyl Alcohol, CI 19140, Faex Extract, Acer Saccharum Extract, Citrus Limon Peel Extract, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract, CI 42090, Citrus Aurantium Dulcis Fruit Extract, CI 17200, Potassium Sorbate