Cetaphil Deep Hydration 48 Hour Activation Serum — Fragrance-Free 1 fl oz, Hyaluronic Acid for Sensitive Skin

Cetaphil Deep Hydration 48 Hour Activation Serum is a lightweight, fragrance-free facial serum that absorbs quickly to help replenish and maintain skin hydration for up to 48 hours.

This fast-absorbing serum is formulated for sensitive skin and features Cetaphil’s HydroSensitiv Complex alongside hyaluronic acid, sunflower seed oil, vitamin B5 and vitamin E to support skin hydration and comfort without heavy residue. It can be used on its own or layered under your usual moisturizer to strengthen skin’s moisture retention and reduce the feeling of tightness associated with dryness.

How does this serum fit into my morning and evening routine?

Apply the serum after cleansing and any thinner treatments (like toners or essences), then follow with a moisturizer and sunscreen in the morning or a cream at night. Its lightweight texture allows quick layering without pilling, so it complements both simple and multi-step routines.

• Use 2–3 drops on clean skin, patting gently until absorbed
• Layer under a broad-spectrum SPF for daytime protection
• Follow with a richer night cream if you need extra moisture

What ingredients help hydrate and soothe sensitive skin?

The formula combines HydroSensitiv Complex with hyaluronic acid to attract water, sunflower seed oil to support the skin barrier, and vitamins B5 and E to comfort and maintain skin appearance. It’s fragrance-free and designed to be gentle on reactive or easily irritated skin.

• Hyaluronic acid: pulls and holds moisture at the skin surface
• Sunflower seed oil: helps fortify the lipid barrier
• Vitamin B5 and E: support skin’s look and resilience
• HydroSensitiv Complex: designed to deepen dynamic hydration

Will this serum clog pores or irritate acne-prone skin?

The serum is formulated to be non-comedogenic and fragrance-free to reduce the risk of pore blockage and irritation. Because it’s lightweight and quickly absorbed, many users find it layers well with acne treatments, though patch-testing is advised for those using active prescriptions.

• Non-comedogenic formulation minimizes pore congestion
• Fragrance-free to lower irritation risk for sensitive skin
• Light texture absorbs rapidly without greasiness

How long before I notice improved hydration and skin feel?

Immediate sensations typically include softer, less tight skin after first applications due to fast absorption and moisture-binding ingredients. Ongoing daily use supports hydration retention and can improve the overall appearance of dehydrated skin over time.

• Instant: skin feels more comfortable and less tight
• Short term (days to weeks): improved smoothness and suppleness
• Works best with consistent twice-daily use and complementary moisturizers

Who is this for: Cetaphil Deep Hydration 48 Hour Activation Serum is suited for people with sensitive, dry, or dehydrated skin looking for a gentle, fragrance-free serum to boost moisture. It’s also a good option if you prefer lightweight skincare that layers easily under creams or sunscreen and want dermatologist-recommended formulations without heavy oils or added fragrances.

Ingredients

Water, Glycerin, Sorbitol, Coco-Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Helianthus Annuus (Sunflower) Seed Oil, Octyldodecanol, Hexyldecanol, Hexyldecyl Laurate, Distarch Phosphate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Butyrospermum Parkii(Shea)Oil, Citric Acid, Dicaprylyl Carbonate, Disodium Cocoyl Glutamate, Globulariaalypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Panthenol (Vitamin B5), Pantolactone, Phenoxyethanol, Propylene Glycol, Sodium Benzoate, Sodium Hydroxide, Sodium Polyacrylate, Tocopherol (Vitamin E), Tocopheryl Acetate (Vitamin E Acetate), Xylitol, Xylitylglucoside