PDRN & Salmon DNA Skincare

PDRN is a DNA-derived ingredient, most often sourced from salmon and sometimes from plants, that Korean brands now add to everything from serums to sleeping masks. In cosmetic skincare it is used to help skin look hydrated, plump and smooth, and it is usually paired with hyaluronic acid, collagen, peptides, niacinamide or centella.

This is the pure PDRN edit: around 280 products that name PDRN on the label, from medicube, REJURAN, VT COSMETICS, mixsoon, Genabelle, TOSOWOONG, CENTELLIAN 24, Abib, COSRX and Dr.Althea. Serums and ampoules form the largest group, followed by creams, hydrogel and jelly masks, under-eye patches, toners, lip treatments and multi-balm sticks. Most cost between about £27 and £48. PDRN sunscreens and scalp products are kept off this page so it stays focused on face care.

If you are new to the ingredient, a serum or essence is the simplest place to start, as it layers under your usual moisturiser. Overnight jelly masks and eye patches suit a once- or twice-weekly treat.

Frequently asked questions

What is PDRN in skincare?

PDRN stands for polydeoxyribonucleotide, a fragment of DNA usually taken from salmon. In cosmetics it is used for hydration and to help skin look smoother and plumper. Cosmetic PDRN products are different from the PDRN injections offered in clinics.

Is salmon DNA the same as PDRN?

Usually, yes. Most PDRN in skincare comes from salmon, which is why products are often labelled 'salmon DNA PDRN'. Some brands use plant-derived PDRN instead.

Can I use PDRN with retinol or vitamin C?

PDRN is generally easy to combine and is often formulated alongside retinal, niacinamide and vitamin C. Introduce one new product at a time and patch test if your skin is sensitive.

Are PDRN products vegan?

Salmon-derived PDRN is not vegan. Several products here use plant-based PDRN and say 'vegan' on the label, so check the product details.