Dr.Reju-All Advanced HPR Retinoid Serum 1 fl oz — Niacinamide 10% & TXA 4% for Anti-Aging and Pore Minimizing, Gentle for Beginner

Dr.Reju-All Advanced Retino-Mela Serum is a next-generation HPR retinoid treatment that targets fine lines, uneven tone, and enlarged pores while remaining gentle enough for retinol beginners.

This compact, science-driven serum combines a stabilized HPR retinoid with 10% niacinamide and 4% tranexamic acid (TXA) to address multiple signs of aging and pigmentation without the usual harshness of traditional retinols. Developed by doctors and pharmacists in Korea and clinically validated for skin compatibility, the formula prioritizes steady improvements in texture, tone, and firmness. It’s fragrance- and colorant-free, non-comedogenic, and designed to integrate smoothly into both starter and experienced regimens.

How does HPR retinol in this serum differ from ordinary retinol?

HPR (hydroxypinacolone retinoate) is a next-gen retinoid that binds directly to retinoid receptors without converting into retinal or retinoic acid first, offering increased stability and reduced irritation. The formulation in this serum is engineered for longer-lasting activity and gentler daily use compared with many classic retinol products.

• 30× greater stability compared with standard retinol in lab stability testing.
• Clinically observed improvements in wrinkle appearance and pore texture.
• Lower irritation risk—suitable for sensitive or retinol-naive skin.

What visible benefits can I expect and how soon?

Consistent nightly use typically yields gradual improvements in fine lines, pore appearance, and uneven tone over several weeks. Some users notice smoother texture and reduced pore visibility within a few weeks, while pigmentation and deeper concerns often require longer-term use for best results.

• Early texture and pore improvements within weeks when used regularly.
• Targeted reduction in dark spots and uneven tone with cumulative use.
• Enhanced overall radiance and refined wrinkles with continued application.

How do the niacinamide and tranexamic acid work with HPR?

Niacinamide supports barrier strength and helps minimize visible pores, while tranexamic acid targets melanin-related discoloration. Together with HPR and alpha-bisabolol, the trio creates a multi-pronged approach: retinoid-driven cell turnover plus active tone control and calming support.

• Niacinamide 10% for pore control, oil regulation, and barrier support.
• TXA 4% to help reduce the appearance of stubborn pigmentation and spots.
• Alpha-bisabolol soothes and reduces potential irritation from active ingredients.

How should I introduce this serum into my routine?

Start slowly if you’re new to retinoids: apply every other night for the first 1–2 weeks, then increase frequency as tolerated. Use it after toner and before moisturizer; if used in the morning, follow with broad-spectrum sunscreen to protect renewed skin from UV damage.

• Suggested layering: Toner → Retino-Mela Serum → PDRN Cream → Barrier Cream.
• Use mainly at night; always apply SPF when used during daytime.
• Patch-test first and adjust frequency to reduce irritation risk.

Who is this for? This serum is ideal for anyone seeking a modern, dermatologist-minded retinoid that balances potency with tolerance: beginners wanting a gentler introduction to retinoids, users focused on visible tone correction and pore refinement, and those preferring fragrance-free, clinically tested K‑beauty formulas. It’s especially suited to people aiming to improve texture and pigmentation while minimizing the common drawbacks of traditional retinol treatments.

Ingredients

Water, Butylene Glycol, Niacinamide, Squalane, Tranexamic Acid, Methyl Trimethicone, Pentylene Glycol, Glycerin, Hydrogenated Ethylhexyl Olivate, Betaine, Propanediol, Dimethyl Isosorbide, C14-22 Alcohols, Bisabolol, Panthenol, Tocopheryl Acetate, 4-t-Butylcyclohexanol, Chondrus Crispus Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glyceryl Stearate, PEG-100 Stearate, Hydrogenated Olive Oil Unsaponifiables, Saccharum Officinarum (Sugarcane) Extract, C12-20 Alkyl Glucoside, 1,2-Hexanediol, Carbomer, Hydroxypinacolone Retinoate, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Adenosine, Palmitic Acid, Stearic Acid, Sorbitan Isostearate, Sodium Hyaluronate, Paeonia Suffruticosa Root Extract, Beta-Glucan, Tocopherol